Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study

Ratib, Sonia and Walker, Alex J. and Card, Timothy R. and Grainge, Matthew J. (2016) Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study. Journal of Hematology and Oncology . ISSN 1756-8722 (In Press)

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Abstract

Background: Venous thromboembolism (VTE) is a well-recognised and life-threatening complication in patients with cancer. However, the precise risk of VTE in hospitalised cancer patients in England has not been previously reported.

Methods: We conducted a cohort study using linked Hospital Episodes Statistics and Office for National Statistics mortality data. We determined the risk of VTE separately for 24 cancer sites following first hospitalisation for cancer (index date) and how this varied by age, proximity from hospital admission, administration of chemotherapy and calendar time.

Results: 3,558,660 patients were hospitalised for cancer between 1998 and 2012. The cancer sites with the highest risk of VTE during initial hospitalisation for cancer were pancreatic (4.9%), ovarian (4%) and liver (3.8%). The three cancer sites with the highest risk of first VTE event within 6 months from discharge, were pancreatic (3.7%), oesophagus (3%) and stomach (2.8%). For most cancers, the risk of VTE within 6 months from discharge was higher amongst patients who underwent chemotherapy compared to those who did not. The impact of age on risk of VTE varied considerably between cancer sites.

Conclusion: The risk of VTE amongst patients hospitalised for cancer varies greatly by cancer site, age, proximity from hospital admission and chemotherapy administration.

Item Type: Article
Keywords: Cancer; Venous thrombosis; Hospitalisation; Epidemiology; Chemotherapy
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
Depositing User: Eprints, Support
Date Deposited: 29 Jul 2016 09:34
Last Modified: 26 Sep 2016 14:50
URI: http://eprints.nottingham.ac.uk/id/eprint/35455

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