Computational modeling of the effects of auditory nerve dysmyelination

Brown, Angus M. and Hamann, Martine (2014) Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in Neuroanatomy, 8 (73). pp. 1-7. ISSN 1662-5129

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Abstract

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conduction property following acoustic over-exposure. Our modeling study infers that changes related to Na+ channel density (rather than the redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels) is the likely cause of the decreased conduction velocity and the conduction block observed after acoustic overexposure (AOE).

Item Type: Article
Additional Information: This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.
Keywords: myelin sheath, hearing loss, node of Ranvier, conduction velocity, conduction block, deafness, myelin domains, action potential
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.3389/fnana.2014.00073
Depositing User: Eprints, Support
Date Deposited: 25 Jul 2016 08:05
Last Modified: 15 Sep 2016 14:56
URI: http://eprints.nottingham.ac.uk/id/eprint/35377

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