A new generation of smart amine donors for transaminase-mediated biotransformations

Gomm, Andrew and Lewis, William and Green, Anthony P. and O'Reilly, Elaine (2016) A new generation of smart amine donors for transaminase-mediated biotransformations. Chemistry - a European Journal . ISSN 1521-3765

[img] PDF - Repository staff only until 14 July 2017. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (403kB)
[img] PDF (Supporting information) - Repository staff only until 14 July 2017. - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (763kB)

Abstract

The application of ω-transaminase biocatalysts for the synthesis of optically pure chiral amines presents a number of challenges, including difficulties associated with displacing the challenging reaction equilibria. Herein, we report a highly effective approach using low equivalents of the novel diamine donor, cadaverine, which enables high conversions of challenging substrates to the corresponding chiral amines in excellent ee. This approach paves the way for the design of self-sufficient fermentation processes combining transaminase biotransformations with existing strategies for cadaverine production via decarboxylation of endogenous lysine.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Gomm, A., Lewis, W., Green, A.P. and O'Reilly, E. (2016), A new generation of smart amine donors for transaminase-mediated biotransformations. Chem. Eur. J., which has been published in final form at doi:10.1002/chem.201603188. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: asymmetric catalysis, biocatalysis, chiral amine, diamine, transaminase
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1002/chem.201603188
Related URLs:
URLURL Type
http://onlinelibrary.wiley.com/doi/10.1002/chem.201603188/abstractPublisher
Depositing User: Bramwell, Roseanna
Date Deposited: 22 Jul 2016 10:08
Last Modified: 01 Dec 2016 22:40
URI: http://eprints.nottingham.ac.uk/id/eprint/35260

Actions (Archive Staff Only)

Edit View Edit View