Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition
Palframan, Matthew J. and Alharthy, Rima D. and Powalowska, Paulina K. and Hayes, Christopher J. (2016) Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition. Organic and Biomolecular Chemistry, 14 . pp. 3112-3119. ISSN 1477-0520
Official URL: http://dx.doi.org/10.1039/C6OB00007J
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification.
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