Neuron-immune mechanisms contribute to pain in early stages of arthritis
Nieto, Francisco R. and Clark, Anna K. and Grist, John and Hathway, Gareth J. and Chapman, Victoria and Malcangio, Marzia (2016) Neuron-immune mechanisms contribute to pain in early stages of arthritis. Journal of Neuroinflammation, 13 . p. 96. ISSN 1742-2094
Background: Rheumatoid arthritis (RA) patients frequently show weak correlations between the magnitude of pain and inflammation suggesting that mechanisms other than overt peripheral inflammation contribute to pain in RA. We assessed changes in microglial reactivity and spinal excitability and their contribution to pain-like behaviour in the early stages of collagen-induced arthritis (CIA) model.
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