A novel role for the immunophilin FKBP52 in motor coordination
Young, Matthew J. and Geiszler, Philippine C. and Pardon, Marie-Christine (2016) A novel role for the immunophilin FKBP52 in motor coordination. Behavioural Brain Research, 313 . pp. 97-110. ISSN 1872-7549
FKBP52 is a ubiquitously distributed immunophilin that has been associated with wideranging functions in cell signalling as well as hormonal and stress responses. Amongst other pathways, it acts via complex-formation with corticosteroid receptors and has consequently been associated with stress- and age-related neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Reduced levels of FKBP52 have been linked to tau dysfunction and amyloid beta toxicity in AD. However, FKBP52’s role in cognition and neurodegenerative disorder-like phenotypes remained to be elucidated.
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