Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries
Alsaqati, M. and Latif, M.L. and Chan, S.L.F. and Ralevic, V. (2014) Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries. British Journal of Pharmacology, 171 (3). pp. 701-713. ISSN 0007-1188
Official URL: http://onlinelibrary.wiley.com/doi/10.1111/bph.12473/abstract;jsessionid=804DA88F606FEAA0EC72BFAE4C608687.f01t02
Background and Purpose: The P2Y14 receptor is the newest member of the P2Y receptor family; it is Gi/o protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5′-diphosphoglucose) (7–10-fold more potent than UDP-glucose). This study investigated whether P2Y14 receptors were functionally expressed in porcine isolated pancreatic arteries.
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