Stepwise evolution of Elk-1 in early deuterostomes
Saxton, Janice and Ferjentsik, Zoltan and Ducker, Charles and Shaw, Peter E. (2016) Stepwise evolution of Elk-1 in early deuterostomes. FEBS Journal, 283 (6). pp. 1025-1038. ISSN 1742-4658
Metazoans have multiple ETS paralogues with overlapping or indiscriminate biological functions. Elk- 1, one of three mammalian Ternary Complex Factors (TCFs), is a well-conserved, ETS domain-containing transcriptional regulator of mitogen-responsive genes that operates in concert with Serum Response Factor (SRF). Nonetheless, its genetic role remains unresolved because the elk-1 gene could be deleted from the mouse genome seemingly without adverse effect. Here we have explored the evolution of Elk-1 to gain insight into its conserved biological role.
Actions (Archive Staff Only)