Cohort profile: the Flu Watch Study

Fragaszy, Ellen B. and Warren-Gash, Charlotte and Wang, Lili and Copas, Andrew and Dukes, Oliver and Edmunds, W. John and Goonetilleke, Nile and Harvey, Gabrielle and Johnson, Anne M. and Kovar, Jana and Lim, Megan S.C. and McMichael, Andrew and Millett, Elizabeth R.C. and Nazareth, Irwin and Nguyen-Van-Tam, Jonathan and Tabassum, Faiza and Watson, John M. and Wurie, Fatima and Zambon, Maria and Hayward, Andrew C. (2016) Cohort profile: the Flu Watch Study. International Journal of Epidemiology . ISSN 0300-5771

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Influenza is a common, highly contagious respiratory virus which infects all age groups, causing a range of outcomes from asymptomatic infection and mild respiratory disease to severe respiratory disease and death.1 If infected, the adaptive immune system produces a humoral (antibody) and cell-mediated (T cell) immune response to fight the infection.2 Influenza viruses continually evolve through antigenic drift, resulting in slightly different ‘seasonal’ influenza strains circulating each year. Population-level antibody immunity to these seasonal viruses builds up over time, so in any given season only a proportion of the population is susceptible to the circulating strains. Occasionally, influenza A viruses evolve rapidly through antigenic shift by swapping genes with influenza viruses usually circulating in animals. This process creates an immunologically distinct virus to which the population may have little to no antibody immunity. The virus can result in a pandemic if a large portion of the population is susceptible and the virus is easily spread.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
Identification Number:
Depositing User: Figgens, Sharon
Date Deposited: 06 Jul 2016 14:20
Last Modified: 17 Sep 2016 18:29

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