Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system

Malys, Mantas Kazimieras and Campbell, Laura and Malys, Naglis (2015) Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system. Medicina, 51 (2). pp. 69-75. ISSN 1010-660X

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution.
Download (468kB) | Preview

Abstract

The human gut commensal microbiota forms a complex population of microorganisms that survive by maintaining a symbiotic relationship with the host. Amongst the metabolic benefits it brings, formation of adaptive immune system and maintenance of its homeostasis are functions that play an important role. This review discusses the integral elements of commensal microbiota that stimulate responses of different parts of the immune system and lead to health or disease. It aims to establish conditions and factors that contribute to gut commensal microbiota's transformation from symbiotic to antibiotic relationship with human. We suggest that the host-microbiota relationship has been evolved to benefit both parties and any changes that may lead to disease, are not due to unfriendly properties of the gut microbiota but due to host genetics or environmental changes such as diet or infection.

Item Type: Article
Keywords: Immune system; Commensal microbiota; T-cells; B-cells; Dysbiosis
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Biomedical Sciences
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.1016/j.medici.2015.03.001
Depositing User: Malys, Naglis
Date Deposited: 06 Jul 2016 07:42
Last Modified: 23 Sep 2016 08:02
URI: http://eprints.nottingham.ac.uk/id/eprint/34650

Actions (Archive Staff Only)

Edit View Edit View