Biomarkers of liver fibrosis
Morling, Joanne R. and Guha, Indra Neil (2016) Biomarkers of liver fibrosis. Clinical Liver Disease, 7 (6). pp. 139-142. ISSN 2046-2484
Official URL: http://onlinelibrary.wiley.com/doi/10.1002/cld.555/full
Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial usage in clinical practice. Additionally, its use is further reduced by sampling error and because histology is in effect a surrogate for clinical outcomes.
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