Biomarkers of liver fibrosis

Morling, Joanne R. and Guha, Indra Neil (2016) Biomarkers of liver fibrosis. Clinical Liver Disease, 7 (6). pp. 139-142. ISSN 2046-2484

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Abstract

Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial usage in clinical practice. Additionally, its use is further reduced by sampling error and because histology is in effect a surrogate for clinical outcomes.

Over recent years, alternative non-invasive biomarkers for the diagnosis of liver fibrosis have been developed. Initially developed in chronic viral hepatitis these have since seen their use expanded to include all aetiologies of CLD. Such markers can be divided into indirect ‘simple’ markers (e.g. transaminases, gamma-glutamyl transferase, platelet count), direct ‘complex’ markers (e.g. procollagen peptides I/III, Type IV collagen), cytokines (e.g. interleukin-10, transforming growth factor alpha) and imaging. Here, we discuss the clinical utility, limitations and development of non-invasive biomarkers in their use as diagnostic and prognostic tests.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Morling, Joanne R. and Guha, Indra N. Biomarkers of liver fibrosis. Clinical Liver Disease Vol. 7, issue 6: 139-142. doi: 10.1002/cld.555 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/cld.555/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Identification Number: https://doi.org/10.1002/cld.555
Depositing User: Morling, Joanne
Date Deposited: 29 Jun 2016 10:04
Last Modified: 17 Sep 2016 18:26
URI: http://eprints.nottingham.ac.uk/id/eprint/34456

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