Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA)

Nwosu, Lilian Ngozi and Mapp, Paul I. and Chapman, Victoria and Walsh, David A. (2016) Relationship between structural pathology and pain behaviour in a model of osteoarthritis (OA). Osteoarthritis and Cartilage . ISSN 1063-4584 (In Press)

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Abstract

Objectives

To address the hypothesis that different types of established OA pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low versus a high dose of monosodium iodoacetate (MIA) in the rat.

Methods

Rats received a single intra-articular injection of 0.1mg or 1mg MIA or saline (control). Pain behaviour (hind limb weight bearing asymmetry (WB) and hindpaw withdrawal threshold (PWT) to punctate stimulation) was assessed. Cartilage and synovium were examined by macroscopic visualisation of articular surfaces and histopathology.

Results

Both doses of MIA lowered PWTs, 1mg MIA also resulted in WB asymmetry. Both doses were associated with cartilage macroscopic appearance, proteoglycan loss, abnormal chondrocyte morphology, increased numbers of vessels crossing the osteochondral junction, synovitis and macrophage infiltration into the synovium. PWTs were more strongly associated with chondrocyte morphology, synovitis and macrophage infiltration than with loss of cartilage surface integrity.

Conclusions

Both pain behaviours were associated with OA structural severity and synovitis. Differences in pain phenotype following low versus higher dose of MIA were identified despite similar structural pathology. OA structural pathology as traditionally measured only partially explains the MIA-induced pain phenotype.

Item Type: Article
Keywords: Pain behaviour; monosodium iodoacetate; synovitis; knee OA; structural pathology
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.1016/j.joca.2016.06.012
Depositing User: Eprints, Support
Date Deposited: 25 Jul 2016 11:05
Last Modified: 14 Sep 2016 15:36
URI: http://eprints.nottingham.ac.uk/id/eprint/34426

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