Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′

Procopiou, George and Aggarwal, Pooja and Newton, Annabella F. and Richards, David and Mellor, Ian R. and Harbottle, Gareth and Stockman, Robert A. (2014) Two-directional synthesis and biological evaluation of alkaloid 5-epi-cis-275B′. Chemical Communications, 50 (97). pp. 15355-15357. ISSN 1364-548X

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Abstract

The first total synthesis of myrmicine ant alkaloid 5-epi-cis-275B0 (4) is presented. A tandem cyclisation stablished the entire core of the structure in a single transformation as well as the required 2,5-anti stereochemistry. Two-directional synthesis was used to furnish the cyclisation precursor 2, as in each of the subsequent steps towards the natural product. The first electrophysiology studies for 4 (against nicotinic acetylcholine receptors) were also conducted, finding modest inhibition of current.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: 10.1039/c4cc07287a
Depositing User: Mellor, Ian
Date Deposited: 26 Jan 2017 14:12
Last Modified: 12 Oct 2017 20:51
URI: http://eprints.nottingham.ac.uk/id/eprint/34270

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