Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices

Chou, I-Jun and Wang, Huei-Shyong and Whitehouse, William P. and Constantinescu, Cris S. (2016) Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16 (7). pp. 1-12. ISSN 1534-6293

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Abstract

Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term treatment is vital to mitigate ongoing neuroinflammation and irreversible neurodegeneration.
However, it may be difficult to early differentiate pediatric MS from acute disseminated
encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorders (NMOSD) as they often have atypical presentation that differs from that of adult-onset MS. The
purpose of this review is to summarize the updated views on diagnostic criteria, imaging, histopathology and treatment choices.

Item Type: Article
Keywords: ADEM; CIS; Demyelination; MRI; NMOSD
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
Identification Number: https://doi.org/10.1007/s11910-016-0663-4
Depositing User: Eprints, Support
Date Deposited: 31 May 2016 10:14
Last Modified: 14 Sep 2016 08:55
URI: http://eprints.nottingham.ac.uk/id/eprint/33485

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