Waiting time distributions for clusters of complex molecules

Thul, Ruediger and Falcke, Martin (2007) Waiting time distributions for clusters of complex molecules. Europhysics Letters, 79 (3). 38003-1-38003-5. ISSN 1286-4854

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Waiting time distributions are in the core of theories for a large variety of subjects ranging from the analysis of patch clamp records to stochastic excitable systems. Here, we present a novel exact method for the calculation of waiting time distributions for state transitions of complex molecules with independent subunit dynamics. The absorbing state is a specific set of subunit states, i.e. is defined on the molecule level. Consequently, we formulate the problem as a random walk in the molecule state space. The subunits can possess an arbitrary number of states and any topology of transitions between them. The method circumvents problems arising from combinatorial explosion due to subunit coupling and requires solutions of the subunit master equation only.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Science > School of Mathematical Sciences
Identification Number: https://doi.org/10.1209/0295-5075/79/38003
Depositing User: Thul, Ruediger
Date Deposited: 24 May 2016 10:06
Last Modified: 14 Sep 2016 03:11
URI: http://eprints.nottingham.ac.uk/id/eprint/33480

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