Impaired burrowing is the most prominent behavioral deficit of aging htau mice
Geiszler, Philippine and Barron, Matthew and Pardon, Marie-Christine (2016) Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience . ISSN 0306-4522
htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to Alzheimer's disease. Whilst histopathological changes in htau mice have been researched in the past, we focused here on functional consequences of human tau accumulation.
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