Low molecular mass nucleoside gelators for intra-tumoural drug delivery
Skilling, Kathryn J. (2016) Low molecular mass nucleoside gelators for intra-tumoural drug delivery. PhD thesis, University of Nottingham.
There are numerous chemotherapeutic agents available today that treat a wide array of tumours. The majority of these compounds are administered via intravenous (i.v.) infusion in large doses (1000 mg/m2), necessary to sustain a desired therapeutic effect. The systemic nature of the drug delivery, the dosage size and non-specific nature of many chemotherapeutic agents however means that they attack any rapidly dividing tissue system, leading to the commonly observed side effects e.g. alopecia, nausea, neutropenia and thrombocytopenia.
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