The role of thin filament sarcomeric proteins tropomyosin 1 and cardiac troponin T in the developing heart
England, Jennifer (2016) The role of thin filament sarcomeric proteins tropomyosin 1 and cardiac troponin T in the developing heart. PhD thesis, University of Nottingham.
The heart is the first functioning organ to develop during embryogenesis to maintain the growing embryo with oxygen and nutrients. However, cardiogenesis is a complex but well-regulated process, and any changes to this regulation can result in detrimental defects of the heart. For many years sarcomeric proteins have been associated with a range of cardiomyopathies and in more recent years are known to been involved in congenital heart defects (CHDs). To date, tropomyosin 1 (TPM1) and cardiac troponin T (TNNT2) have been associated with cardiomyopathies but never with CHDs. These two genes are important regulatory proteins of the thin filament of the sarcomere and vital for correct contraction and force generation within cardiomyocytes.
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