Glycosylated notch and cancer

Pakkiriswami, Shanmugasundaram and Couto, Africa and Nagarajan, Usha and Georgiou, Marios (2016) Glycosylated notch and cancer. Frontiers in Oncology, 6 (37). ISSN 2234-943X

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Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis.

Item Type: Article
Keywords: Glycosyltransferases; Notch signaling; Tumorigenesis; Epidermal growth factor
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
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Depositing User: Eprints, Support
Date Deposited: 20 Apr 2016 09:45
Last Modified: 14 Sep 2016 11:57

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