Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin

Farr, Tracy D. and Lai, Chian-Hui and Grünstein, Dan and Orts-Gil, Guillermo and Wang, Cheng-Chung and Boehm-Sturm, Philipp and Seeberger, Peter H. and Harms, Christoph (2014) Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Letters, 14 (4). pp. 2130-2134. ISSN 1530-6992

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Abstract

Activation of the endothelium is a pivotal first step for leukocyte migration into the diseased brain. Consequently, imaging this activation process is highly desirable. We synthesized carbohydrate-functionalized magnetic nanoparticles that bind specifically to the endothelial transmembrane inflammatory proteins E and P selectin. Magnetic resonance imaging revealed that the targeted nanoparticles accumulated in the brain vasculature following acute administration into a clinically relevant animal model of stroke, though increases in selectin expression were observed in both brain hemispheres. Nonfunctionalized naked particles also appear to be a plausible agent to target the ischemic vasculature. The importance of these findings is discussed regarding the potential for translation into the clinic.

Item Type: Article
Additional Information: This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Nano Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see http://dx.doi.org/10.1021/nl500388h
Keywords: Glyco-magnetic nanoparticle; MRI; Stroke; Selection; Nano-medicine
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number: https://doi.org/10.1021/nl500388h
Depositing User: Eprints, Support
Date Deposited: 15 Apr 2016 14:19
Last Modified: 29 Nov 2016 15:33
URI: http://eprints.nottingham.ac.uk/id/eprint/32797

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