Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Artigas, María Soler and Wain, Louise V. and Miller, Suzanne and Kheirallah, Abdul Kader and Huffman, Jennifer E. and Ntalla, Ioanna and Shrine, Nick and Obeidat, Ma’en and Trochet, Holly and McArdle, Wendy L. and Alves, Alexessander Couto and Hui, Jennie and Zhao, Jing Hua and Joshi, Peter K. and Teumer, Alexander and Albrecht, Eva and Imboden, Medea and Rawal, Rajesh and Lopez, Lorna M. and Marten, Jonathan and Enroth, Stefan and Surakka, Ida and Polasek, Ozren and Lyytikäinen, Leo-Pekka and Granell, Raquel and Hysi, Pirro G. and Flexeder, Claudia and Mahajan, Anubha and Beilby, John and Bossé, Yohan and Brandsma, Corry-Anke and Campbell, Harry and Gieger, Christian and Gläser, Sven and González, Juan R. and Grallert, Harald and Hammond, Chris J. and Harris, Sarah E. and Hartikainen, Anna-Liisa and Heliövaara, Markku and Henderson, John and Hocking, Lynne and Horikoshi, Momoko and Hutri-Kähönen, Nina and Ingelsson, Erik and Johansson, Åsa and Kemp, John P. and Kolcic, Ivana and Kumar, Ashish and Lind, Lars and Melén, Erik and Musk, Arthur W. and Navarro, Pau and Nickle, David C. and Padmanabhan, Sandosh and Raitakari, Olli T. and Ried, Janina S. and Ripatti, Samuli and Schulz, Holger and Scott, Robert A. and Sin, Don D. and Starr, John M. and Deloukas, Panos and Hansell, Anna L. and Hubbard, Richard and Jackson, Victoria E. and Marchini, Jonathan and Pavord, Ian and Thomson, Neil C. and Zeggini, Eleftheria and Viñuela, Ana and Völzke, Henry and Wild, Sarah H. and Wright, Alan F. and Zemunik, Tatijana and Jarvis, Deborah L. and Spector, Tim D. and Evans, David M. and Lehtimäki, Terho and Vitart, Veronique and Kähönen, Mika and Gyllensten, Ulf and Rudan, Igor and Deary, Ian J. and Karrasch, Stefan and Probst-Hensch, Nicole M. and Heinrich, Joachim and Stubbe, Beate and Wilson, James F. and Wareham, Nicholas J. and James, Alan L. and Morris, Andrew P. and Jarvelin, Marjo-Riitta and Hayward, Caroline and Sayers, Ian and Strachan, David P. and Hall, Ian P. and Tobin, Martin D. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6 . 8658/1-8658/12. ISSN 2041-1723

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Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Respiratory Medicine
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Depositing User: Eprints, Support
Date Deposited: 05 Apr 2016 13:28
Last Modified: 23 Oct 2016 22:58

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