Abnormal visuomotor processing in schizophrenia

Robson, Siân E. and Brookes, Matthew J. and Hall, Emma L. and Palaniyappan, Lena and Kumar, Jyothika and Skelton, Michael and Christodoulou, Nikolaos G. and Qureshi, Ayaz and Jan, Fiesal and Katshu, Mohammad Z. and Liddle, Elizabeth B. and Liddle, Peter F. and Morris, Peter G. (2015) Abnormal visuomotor processing in schizophrenia. NeuroImage: Clinical . ISSN 2213-1582

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Abstract

Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post movement beta rebound (PMBR)); while in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a selfpaced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm

Item Type: Article
Keywords: Schizophrenia, magnetoencephalography, motor cortex, visual cortex, electrophysiological processes
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Psychiatry
University of Nottingham UK Campus > Faculty of Science > School of Physics and Astronomy
Identification Number: https://doi.org/10.1016/j.nicl.2015.08.005
Depositing User: Eprints, Support
Date Deposited: 23 Mar 2016 13:34
Last Modified: 13 Sep 2016 15:09
URI: http://eprints.nottingham.ac.uk/id/eprint/32487

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