Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases

Guerreiro, Rita and Escott-Price, Valentina and Darwent, Lee and Parkkinen, Laura and Ansorge, Olaf and Hernandez, Dena and Nalls, Michael A. and Clark, Lorraine and Honig, Lawrence and Marder, Karen and Flier, Wiesje van der and Holstege, Henne and Louwersheimer, Eva and Lemstra, Afina and Scheltens, Philip and Barber, Imelda S. and Braae, Anne and Brown, Kristelle and Morgan, Kevin (2016) Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Alzheimer’s and Parkinson’s diseases. Neurobiology of Aging, 38 . p. 214. ISSN 1558-1497

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Abstract

The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.

Item Type: Article
Keywords: Dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; Genetic correlation
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences > Human Genetics Research Group
Identification Number: https://doi.org/10.1016/j.neurobiolaging.2015.10.028
Depositing User: Morgan, Kevin
Date Deposited: 14 Mar 2016 12:06
Last Modified: 13 Sep 2016 17:07
URI: http://eprints.nottingham.ac.uk/id/eprint/32269

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