Tandem reactions for sp3-rich scaffold synthesis
Bawazeer, Wafa Abubaker S. (2016) Tandem reactions for sp3-rich scaffold synthesis. PhD thesis, University of Nottingham.
Several novel methodologies were explored with the general purpose of rapid access to molecular complexity and sp3-rich scaffolds. A number of novel scaffolds were successfully synthesised, utilising two-directional synthesis and tandem reactions. The chemistries applied have been demonstrated to be capable of readily fabricating many novel and interesting diverse molecular scaffolds. Indeed, the azaspirocyclic cores found in halichlorine and pinnaic acid were synthesised using this approach starting with ethyl formate.
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