Catecholaminergic depletion in nucleus accumbens enhances trace conditioning
Nelson, Andrew J.D. and Thur, Karen E. and Spicer, C. and Marsden, C.A. and Cassaday, Helen J. (2011) Catecholaminergic depletion in nucleus accumbens enhances trace conditioning. Advances in Medical Sciences, 56 (1). pp. 71-79. ISSN 1896-1126
Official URL: http://www.degruyter.com/view/j/ams.2011.56.issue-1/v10039-011-0014-2/v10039-011-0014-2.xml
Purpose: To examine the effect of dopamine depletion in nucleus accumbens on trace conditioning; to distinguish the role of core and shell sub-regions, as far as possible. Material/Methods: 6-hydroxydopamine was used to lesion dopamine terminals within the core and shell accumbens. Experiment 1 assessed conditioning to a tone conditioned stimulus that had previously been paired with footshock (unconditioned stimulus) at a 30s trace interval. Experiment 2 subsequently assessed contiguous conditioning (at 0s trace) using a light conditioned stimulus directly followed by the unconditioned stimulus.
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