The immune response to Mycobacterium avium induced in avian and human macrophage-like cell lines and in chickens
Shukur, Mohammed Shukri (2016) The immune response to Mycobacterium avium induced in avian and human macrophage-like cell lines and in chickens. PhD thesis, University of Nottingham.
Avian tuberculosis remains a significant economic problem for the poultry industry in many countries. An improved understanding of the interaction between host and mycobacteria is important in designing more efficient vaccine strategies. This study investigated the immune responses to M. avium (Ma.) strains isolated from different sources, Ma strains 1-2 isolated from chickens, Ma.3-5 from cattle and Ma.6-8 from humans, using human cells in vitro and avian cells in vitro and in vivo. The responses were characterised by expression levels of pro-inflammatory cytokines tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-6 and chemokines CXCLi1 (K60) and CXCLi2 (IL-8) and nitric oxide production.
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