Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma
Smith, Stuart J. and Rahman, Cheryl V. and Clarke, Alison A. and Gould, Toby W. and Ward, Jennifer H. and Shakesheff, Kevin M. and Grundy, Richard G. and Rahman, Ruman (2014) Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma. Annals of the Royal College of Surgeons of England, 96 (7). pp. 495-501. ISSN 1478-7083
Introduction: The median survival of patients with glioblastoma multiforme (astrocytoma grade 4) remains less than 18 months despite radical surgery, radiotherapy and systemic chemotherapy. Surgical implantation of chemotherapy eluting wafers into the resection cavity has been shown to improve length of survival but the current licensed therapy has several drawbacks. This paper investigates in vivo efficacy of a novel drug eluting paste in glioblastoma.
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