Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis

Hurley, M.N., Amin Ariff, A.H., Bertenshaw, C., Bhatt, J. and Smyth, Alan R. (2012) Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis. Journal of Cystic Fibrosis, 11 (4). pp. 288-292. ISSN 1873-5010

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Introduction: Patients with CF experience pulmonary exacerbations. These are often initially empirically treated with intravenous antibiotics, with antibiotic choice refined after susceptibility testing.

Methods: We completed a 5-year retrospective review of children attending the Paediatric CF Unit, Nottingham. The respiratory sampling, antibiotic prescribing and susceptibility testing guidance were audited. Episodes were classified according to the concordance between the antibiotics prescribed and antibiotic susceptibility testing.

Results: Of 52 patients who had previously isolated Pseudomonas aeruginosa, 103 antibiotic courses were commenced that coincided with an isolation of P. aeruginosa. P. aeruginosa was fully susceptible, partially susceptible or fully resistant on 33%, 44.7% or 16.5% of occasions respectively. The antibiotic prescriptions were never changed following antibiotic susceptibility testing. We found no association between change in FEV1 (p = 0.54), change in BMI (p = 0.12) or time to next exacerbation (p = 0.66) and concordance between antibiotic susceptibility and the antibiotics administered.

Conclusion: This study contributes to mounting evidence questioning the utility of routine antibiotic susceptibility testing.

Item Type: Article
Keywords: Cystic fibrosis, Antibiotic, Susceptibility testing, Pseudomonas
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number:
Depositing User: Chamberlain, Mr Dick
Date Deposited: 21 May 2014 10:16
Last Modified: 04 May 2020 20:21

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