Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Hurley, M.N. and Camara, Miguel and Smyth, Alan R. (2012) Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. European Respiratory Journal, 40 (4). pp. 1014-1023. ISSN 0903-1936

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Abstract

Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action. This review addresses some of the latest research developments on the exploitation of candidate adjuvant therapeutic agents that may act alongside conventional antibiotics as an alternative therapeutic strategy. After considering key mechanisms this opportunistic pathogen employs to control virulence, the progress of various strategies including the inhibition of quorum sensing, efflux pumps and lectins, and the use of iron chelators, bacteriophages, immunisation and immunotherapy is reviewed. Both therapeutic approaches in early development and clinical phase are discussed.

Item Type: Article
Keywords: Antibiotic resistance, Antibiotic treatment, Cystic fibrosis and chronic infections, Pseudomonas
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Chamberlain, Mr Dick
Date Deposited: 21 May 2014 10:43
Last Modified: 15 Sep 2016 15:51
URI: http://eprints.nottingham.ac.uk/id/eprint/3173

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