Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing

Brown, Katherine and Moreton, Joanna and Malla, Sunir and Aboobaker, A. Aziz and Emes, Richard D. and Tarlinton, Rachael E. (2012) Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing. Virology, 433 (1). pp. 55-63. ISSN 0042-6822

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Abstract

The recently released draft horse genome is incompletely characterised in terms of its repetitive

element profile. This paper presents characterisation of the endogenous retrovirus (ERVs) of the horse

genome based on a data-mining strategy using murine leukaemia virus proteins as queries. 978 ERV

gene sequences were identified. Sequences were identified from the gamma, epsilon and betaretrovirus

genera. At least one full length gammaretroviral locus was identified, though the gammaretroviral

sequences are very degenerate. Using these data the RNA expression of these ERVs were derived from

RNA transcriptome data from a variety of equine tissues. Unlike the well studied human and murine

ERVs there do not appear to be particular phylogenetic groups of equine ERVs that are more

transcriptionally active. Using this novel approach provided a more technically feasible method to

characterise ERV expression than previous studies.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Identification Number: https://doi.org/10.1016/j.virol.2012.07.010
Depositing User: Tarlinton, Dr Rachael
Date Deposited: 21 Jul 2015 09:46
Last Modified: 10 Dec 2016 22:05
URI: http://eprints.nottingham.ac.uk/id/eprint/3169

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