The effect of secreted products from Pseudomons aeruginosa on immune cells
Hussain, Farah (2016) The effect of secreted products from Pseudomons aeruginosa on immune cells. PhD thesis, University of Nottingham.
Pseudomonas aeruginosa is an opportunistic pathogen that represents a major burden to the healthcare system as it accounts for a vast number of hospital-acquired infections. P. aeruginosa is a particular threat in Cystic Fibrosis (CF) patients. This bacterium expresses an arsenal of secreted virulence factors that play a fundamental role in the invasion of the damaged physical barriers of the host and abrogate immune responses which aid the persistence of P. aeruginosa infections. The aim of this study is to elucidate the role of P. aeruginosa secretions in the modulation of the immune system and determine the key factors and their specific impact on immune cells such as T helper cells proliferation and monocytes viability.
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