Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma
Lilburn, David M.L. and Tatler, Amanda L. and Six, Joseph S. and Lesbats, Clémentine and Habgood, Antony and Porte, Joanne and Hughes-Riley, Theodore and Shaw, Dominick E. and Jenkins, Gisli and Meersmann, Thomas (2015) Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine . ISSN 1522-2594
Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independent of confounding systemic considerations but also to reduce animal numbers and associated research costs. In this work a straightforward laboratory method is advanced to probe dynamic changes in gas inhalation patterns by utilizing an ex vivo small animal ovalbumin (OVA) model of human asthma.
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