Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer

Zamberlan, Francesco and Lesbats, Clémentine and Rogers, Nicola J. and Krupa, James L. and Pavlovskaya, Galina E. and Thomas, Neil R. and Faas, Henryk and Meersmann, Thomas (2015) Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16 (11). pp. 2294-2298. ISSN 1439-7641

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Abstract

A new approach for hyperpolarized 129Xe molecular sensors is explored using paramagnetic relaxation agents that can be deactivated upon chemical or enzymatic reaction with an analyte. Cryptophane encapsulated 129Xe within the vicinity of the paramagnetic center experiences fast relaxation that, through chemical exchange of xenon atoms between cage and solvent pool, causes accelerated hyperpolarized 129Xe signal decay in the dissolved phase. In this work, the relaxivity of GadoliniumIII-DOTA on 129Xe in the solvent was increased eightfold through tethering of the paramagnetic molecule to a cryptophane cage. This potent relaxation agent can be ‘turned off’ specifically for 129Xe through chemical reactions that spatially separate the GdIII centre from the attached cryptophane cage. Unlike 129Xe chemical shift based sensors, the new concept does not require high spectral resolution and may lead to a new generation of responsive contrast agents for molecular MRI.

Item Type: Article
Additional Information: This is the pre-peer reviewed version of the following article: Zamberlan, F., Lesbats, C., Rogers, N. J., Krupa, J. L., Pavlovskaya, G. E., Thomas, N. R., Faas, H. M. and Meersmann, T. (2015), Molecular sensing with hyperpolarized 129Xe using switchable chemical exchange relaxation transfer. ChemPhysChem, 16: 2294–2298. doi:10.1002/cphc.201500367, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/cphc.201500367/abstract
Keywords: Hyperpolarized xenon biosensor • MRI contrast agent • cryptophane • HyperCEST • molecular imaging
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Clinical Neuroscience
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine > Division of Respiratory Medicine
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine
University of Nottingham UK Campus > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1002/cphc.201500367
Related URLs:
URLURL Type
http://www.interscience.wiley.com/Publisher
Depositing User: Meersmann, Thomas
Date Deposited: 05 Feb 2016 15:03
Last Modified: 15 Sep 2016 03:59
URI: http://eprints.nottingham.ac.uk/id/eprint/31550

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