A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis
Chang, William Y.C. and Cane, Jennifer L. and Kumaran, Maruti and Lewis, Sarah and Tattersfield, Anne E. and Johnson, Simon R. (2014) A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis. European Respiratory Journal, 43 (4). pp. 1114-1123. ISSN 1399-3003
Official URL: http://erj.ersjournals.com/content/43/4/1114
Lymphangioleiomyomatosis (LAM) is characterised by lung cysts and airflow obstruction. Matrix metalloproteinases have been implicated in lung destruction in LAM. We performed a randomised, double-blind trial, comparing the matrix metalloproteinases inhibitor doxycycline with placebo on the progression of LAM.
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