Total loss of MHC class I is an independent indicator of good prognosis in breast cancer

Madjd, Zahra, Spendlove, Ian, Pinder, Sarah E., Ellis, Ian O. and Durrant, Lindy G. (2005) Total loss of MHC class I is an independent indicator of good prognosis in breast cancer. International Journal of Cancer, 117 (2). pp. 248-255. ISSN 0020-7136

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Abstract

Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast, loss of MHC Class I results in NK activation. In our study a large set of samples from patients with primary operable invasive breast cancer was evaluated for the expression of MHC Class I heavy and light by immunohistochemical staining of 439 breast carcinomas in a tissue microarray. Forty-seven percent (206 of 439) of breast carcinomas were considered negative for HLA Class I heavy chain (HC10), whereas lack of anti-β2m-antibody staining was observed in 39% (167 of 424) of tumours, with only 3% of the β2m-negative tumours expressing detectable HLA Class I heavy chain. Correlation with patient outcome showed direct relationship between patient survival and HLA-negative phenotype (log rank = 0.004). A positive relationship was found between the intensity of expression of MHC Class I light and heavy chains expression and histological grade of invasive tumour (p < 0.001) and Nottingham Prognostic Index (p < 0.001). To investigate whether HLA Class I heavy and light chains expression had independent prognostic significance, Cox multivariate regression analysis, including the parameters of tumour size, lymph node stage, grade and intensity of HC10 and anti-β2m staining, was carried out. In our analysis, lymph node stage (p < 0.001), tumour grade (p = 0.005) and intensity of MHC Class I light and heavy chains expression were shown to be independent prognostic factors predictive of overall survival (p-values HC10 = 0.047 and β2m = 0.018).

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/703470
Keywords: Breast tissue microarray, HC10, Prognostic factor, MHC Class I, Immunohistochemistry
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: https://doi.org/10.1002/ijc.21163
Depositing User: Liu, Mr Zhenxing
Date Deposited: 09 May 2014 09:47
Last Modified: 04 May 2020 16:26
URI: https://eprints.nottingham.ac.uk/id/eprint/3145

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