Whole genome sequence and manual annotation of Clostridium autoethanogenum, an industrially relevant bacterium
Humphreys, Christopher M. and McLean, Samantha and Schatschneider, Sarah and Millat, Thomas and Henstra, Anne M. and Annan, Florence J. and Breitkopf, Florence and Pander, Bart and Piatek, Pawel and Rowe, Peter and Wichlacz, Alexander T. and Woods, Craig and Norman, Rupert and Blom, Jochen and Goesman, Alexander and Hodgman, Charlie and Barrett, David and Thomas, Neil R. and Winzer, Klaus and Minton, Nigel P. (2015) Whole genome sequence and manual annotation of Clostridium autoethanogenum, an industrially relevant bacterium. BMC Genomics, 16 . 1085/1-1085/10. ISSN 1471-2164
Clostridium autoethanogenum is an acetogenic bacterium capable of producing high value commodity chemicals and biofuels from the C1 gases present in synthesis gas. This common industrial waste gas can act as the sole energy and carbon source for the bacterium that converts the low value gaseous components into cellular building blocks and industrially relevant products via the action of the reductive acetyl-CoA (Wood-Ljungdahl) pathway. Current research efforts are focused on the enhancement and extension of product formation in this organism via synthetic biology approaches. However, crucial to metabolic modelling and directed pathway engineering is a reliable and comprehensively annotated genome sequence.
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