An apoferritin-based drug delivery system for the tyrosine kinase inhibitor Gefitinib

Kuruppu, Anchala I. and Zhang, Lei and Collins, Hilary M. and Turyanska, Lyudmila and Thomas, Neil. R. and Bradshaw, Tracey D. (2015) An apoferritin-based drug delivery system for the tyrosine kinase inhibitor Gefitinib. Advanced Healthcare Materials, 4 (18). pp. 2816-2821. ISSN 2192-2659

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Abstract

Development of a tumor-specific drug delivery system is challenging and depends immensely on the carrier. Currently various approaches are considered to develop efficient drug delivery systems. Leaky vasculature, associated with sustained tumor angiogenesis together with tumor-associated poor lymphatic drainage can enhance passive targeting of nanoparticles (NPs) to malignant tissue resulting in the enhanced permeability retention effect. Nanoparticulate drug formulations, exploiting this feature of the tumor microenvironment, can be used to deliver chemotherapeutic agents to tumor target sites thereby increasing the therapeutic effect while minimizing systemic toxicitie. When selecting a delivery system a major consideration is controlled release of the drug to the target site at a therapeutically optimal rate

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Kuruppu, A. I., Zhang, L., Collins, H., Turyanska, L., Thomas, N. R. and Bradshaw, T. D. (2015), An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib. Advanced Healthcare Materials, 4: 2816–2821. doi: 10.1002/adhm.201500389 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/adhm.201500389/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: apoferritin, Gefitinib, nanoparticles, breast cancer, drug delivery system
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Chemistry
Identification Number: https://doi.org/10.1002/adhm.201500389
Depositing User: Bramwell, Roseanna
Date Deposited: 13 Jan 2016 15:06
Last Modified: 03 Dec 2016 02:38
URI: http://eprints.nottingham.ac.uk/id/eprint/31245

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