A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites
Winter, Alan D. and Gillan, Victoria and Maitland, Kirsty and Emes, Richard D. and Roberts, BBrett and McCormack, Gillian and Weir, William and Prostaio, Anna V. and Holroyd, Nancy and Berriman, Matthew and Britton, Collette and Devaney, Eileen (2015) A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics, 16 . e331/1-e331/15. ISSN 1471-2164
Background: Filarial nematodes are important pathogens in the tropics transmitted to humans via the bite of blood sucking arthropod vectors. The molecular mechanisms underpinning survival and differentiation of these parasites following transmission are poorly understood. microRNAs are small non-coding RNA molecules that regulate target mRNAs and we set out to investigate whether they play a role in the infection event.
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