DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS
Glossop, John R. and Haworth, Kim E. and Emes, Richard D. and Nixon, Nicola B. and Packham, Jon C. and Dawes, Peter T. and Fryer, Anthony A. and Mattey, Derek L. and Farrell, William E. (2015) DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS. Epigenomics, 7 (4). pp. 539-551. ISSN 1750-1911
Official URL: http://www.futuremedicine.com/doi/10.2217/epi.15.15
Aims: Alterations in DNA methylation contribute to the abnormal phenotype of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). Herein, we performed genome-wide DNA methylation profiling of RA FLS derived from synovial fluid, a more readily accessible source of disease-associated cells.
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