Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks
Van Nuffel, Sebastiaan and Parmenter, Christopher and Scurr, David J. and Russell, Noah A. and Zelzer, Mischa (2015) Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks. Analyst, 141 (1). pp. 90-95. ISSN 1364-5528
Advanced data analysis tools are crucial for the application of ToF-SIMS analysis to biological samples. Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of neuronal cell cultures. The method readily provides access to sample component information and significantly improves the images’ signal-to-noise ratio (SNR).
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