Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment

Magennis, E.P. and Hook, A.L. and Davies, M.C. and Alexander, C. and Williams, P. and Alexander, M.R. (2016) Engineering serendipity: high-throughput discovery of materials that resist bacterial attachment. Acta Biomaterialia, 34 . pp. 84-92. ISSN 1878-7568

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Abstract

Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood, limiting the ab initio design and engineering of biomaterials to control bacterial attachment. Combinatorial approaches involving high-throughput screening have emerged as key tools for identifying materials to control bacterial attachment. The hundreds of different materials assessed using these methods can be carried out with the aid of computational modelling. This approach can develop an understanding of the rules used to predict bacterial attachment to surfaces of non-toxic synthetic materials. Here we outline our view on the state of this field and the challenges and opportunities in this area for the coming years.

Item Type: Article
Keywords: Biomaterials, Bacteria, High-throughput, Biofilm, Polymers
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences
University of Nottingham UK Campus > Faculty of Science > School of Pharmacy
Identification Number: https://doi.org/10.1016/j.actbio.2015.11.008
Depositing User: Magennis, Peter
Date Deposited: 30 Nov 2015 11:00
Last Modified: 14 Sep 2016 01:37
URI: http://eprints.nottingham.ac.uk/id/eprint/30948

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