Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes
Glossop, John R. and Emes, Richard D. and Nixon, Nicola B. and Packham, Jon C. and Fryer, Anthony A. and Mattey, Derek L. and Farrell, William E. (2016) Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes. Epigenomics, 8 (2). pp. 209-224. ISSN 1750-192X
Official URL: http://www.futuremedicine.com/doi/10.2217/epi.15.103
AIM: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease. Following recent investigations of T- and B-lymphocytes in established disease, we now characterize in these cell populations genome-wide DNA methylation in treatment-naive patients with early RA.
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