Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle

Lehmann, Susann and Bass, Joseph J. and Szewczyk, N.J. (2013) Knockdown of the C. elegans kinome identifies kinases required for normal protein homeostasis, mitochondrial network structure, and sarcomere structure in muscle. Cell Communication & Signaling, 11 (71). ISSN 1478-811X

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Abstract

Kinases are important signalling molecules for modulating cellular processes and major targets of drug discovery programs. However, functional information for roughly half the human kinome is lacking. We conducted three kinome wide, >90%, RNAi screens and epistasis testing of some identified kinases against known intramuscular signalling systems to increase the functional annotation of the C. elegans kinome and expand our understanding of kinome influence upon muscle protein degradation.

Item Type: Article
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Medicine
Depositing User: Grogan, Mrs Jane
Date Deposited: 30 Apr 2014 12:27
Last Modified: 16 Sep 2016 00:57
URI: http://eprints.nottingham.ac.uk/id/eprint/3089

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