High throughput methods applied in biomaterial development and discovery
Hook, Andrew L. and Anderson, Daniel G. and Langer, Robert and Williams, Paul and Davies, Martyn C. and Alexander, Morgan R. (2010) High throughput methods applied in biomaterial development and discovery. Biomaterials, 31 (2). pp. 187-198. ISSN 1878-5905
The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the literature in this area and conclude that for polymers, this process is best achieved in a microarray format, which enable thousands of cell-material interactions to be monitored on a single chip. Polymer microarrays can be formed by printing pre-synthesised polymers or by printing monomers onto the chip where on-slide polymerisation is initiated.
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