The proliferation and differentiation responses of adult mouse neural stem cells in vitro

Chou, Robert Chang-Chih (2015) The proliferation and differentiation responses of adult mouse neural stem cells in vitro. MPhil thesis, University of Nottingham.

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Abstract

Recent studies have shown that the adult brain retains a population of stem cells in specific locations. Adult neural stem cells (NSCs) from the subventricular zone of the lateral ventricle have self-renewing and differentiation capability. These NSCs are capable of differentiating into astrocytes, oligodendrocytes and neurons in vitro. Study the proliferation and differentiation capability of the adult NSCs would provide a resource for developing new treatments for neurodegenerative diseases in the future. Retinoic acid has been described to promote neuron formation from the several different types of stem cell in vitro. Recently, a novel synthetic analogue EC23 has been released. However, the impact of EC23 on neuron formation and cell growth remain unclear. This project focuses on comparing the pro-neurogenic capability and impact on cell growth and cell cycle of EC23 with Retinoic acid and preliminary evaluating the character of PPARγ in Retinoid-induced neuron formation by using PPARγ agonist Rosiglitazone.

Item Type: Thesis (University of Nottingham only) (MPhil)
Supervisors: Sottile, Virginie
Tufarelli, Cristina
Keywords: Adult neural stem cells, Proliferation, Differentiation, EC23, Retinoic acid
Subjects: Q Science > QH Natural history. Biology > QH573 Cytology
Faculties/Schools: UK Campuses > Faculty of Medicine and Health Sciences > School of Medicine
Item ID: 30680
Depositing User: Chou, Robert
Date Deposited: 13 Jan 2016 15:16
Last Modified: 20 Sep 2016 00:38
URI: http://eprints.nottingham.ac.uk/id/eprint/30680

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