Structural and pain modifications in models of osteoarthritis
Nwosu, Lilian Ngozi (2015) Structural and pain modifications in models of osteoarthritis. PhD thesis, University of Nottinngham.
Background: Despite the extensive research into the pathophysiology of osteoarthritis (OA), pain still represents a significant unmet clinical need. This thesis explores the effects of a tropomyosin related kinase A receptor (TrkA) inhibitor and an anti-nerve growth factor (NGF) antibody as interventions to modify inflammation, structural pathology and pain behaviour in rat models of OA.
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