Troubleshooting methods for the generation of novel pseudotyped viruses

King, Barnabas and Temperton, Nigel and Grehan, Keith and Scott, Simon and Wright, Edward and Tarr, Alexander W. and Daly, Janet M. (2016) Troubleshooting methods for the generation of novel pseudotyped viruses. Future Virology . pp. 1-35. ISSN 1746-0808 (In Press)

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Abstract

A pseudotyped virus (PV) is a virus particle with an envelope protein originating from a different virus. The ability to dictate which envelope proteins are expressed on the surface has made pseudotyping an important tool for basic virological studies such as determining the cellular targets of the envelope protein of the virus as well as identification of potential antiviral compounds and measuring specific antibody responses. In this review, we describe the common methodologies employed to generate PVs, with a focus on approaches to improve the efficacy of PV generation.

Item Type: Article
Additional Information: Article has been submitted for publication to Future Virology.
Keywords: Pseudotyped virus, pseudotypes, pseudoparticles, envelope glycoproteins
Schools/Departments: University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Life Sciences
University of Nottingham UK Campus > Faculty of Medicine and Health Sciences > School of Veterinary Medicine and Science
Related URLs:
URLURL Type
http://www.futuremedicine.com/loi/fvlUNSPECIFIED
Depositing User: Daly, Janet
Date Deposited: 30 Oct 2015 09:38
Last Modified: 14 Sep 2016 02:06
URI: http://eprints.nottingham.ac.uk/id/eprint/30590

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