Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype
Shohayeb, Belal (2015) Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype. MRes thesis, University of Nottingham.
Cell polarity impacts on the maintenance of cell shape, cell-cell junction integrity, and protrusions formation and dynamics. Further, polarity regulates cell movement, proliferation and differentiation. Conversely when cells lose their polarity they may be susceptible to dysfunction that may underlie degenerative disorders and tumour progression. Cell polarity and polarity protein complexes are highly conserved between different organisms from unicellular to multicellular, and from invertebrates to vertebrates. The focus of this study is the apico-basal polarity that is established normally in epithelial cells.
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