Synthesis and biological evaluation of enantiopure substituted titanocene complexes
Cini, Melchior (2015) Synthesis and biological evaluation of enantiopure substituted titanocene complexes. PhD thesis, University of Nottingham.
Tolerated by normal tissues, implementation of anti-cancer therapies based on titanium compounds is limited by low efficacy/selectivity, lack of understanding of their mode(s) of action and access to the most active chiral variants. This thesis reports the synthesis, characterization and biological evaluation of a novel class of chiral substituted titanocenes from novel chiral cyclopentadienyl ligands, themselves accessible from substituted pentafulvenes.
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