Design, synthesis and applications of hydroxylmethyl-aryl phosphine oxides in phosphorus catalysis

Chapman, Charlotte Grace (2015) Design, synthesis and applications of hydroxylmethyl-aryl phosphine oxides in phosphorus catalysis. PhD thesis, University of Nottingham.

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Organophosphorus-mediated reactions are important tools in organic chemistry and are used in the synthesis of highly desirable drug targets, such as morphine.1 A major drawback of traditional phosphorus-mediated reactions is the formation of stoichiometric amounts of phosphine oxide by-products; this renders the product purification difficult and reduces the atom efficiency of these transformations. For these reasons, catalytic variants become desirable; there being two potential strategies to achieve the catalysis; i) redox-driven and ii) redox-neutral.2-4 The redox-driven catalytic cycle requires a reductant for the turnover whilst the redox-neutral system uses a sacrificial reagent to directly turn over the phosphine oxide to the active phosphorus (V) reagent. This thesis will report upon a new class of Hydroxylmethyl-Aryl phosphine 1 and phosphine oxide 3 catalyst for use in a redox-driven catalytic reaction; the Staudinger reduction Scheme 1, and routes to a potential redox-neutral catalytic Mitsunobu reaction Scheme 2.

Item Type: Thesis (University of Nottingham only) (PhD)
Supervisors: Denton, R.
Stockman, R.A.
Keywords: Phosphorus, catalysis
Subjects: Q Science > QD Chemistry > QD146 Inorganic chemistry
Q Science > QD Chemistry > QD450 Physical and theoretical chemistry
Faculties/Schools: UK Campuses > Faculty of Science > School of Chemistry
Item ID: 30361
Depositing User: Chapman, Charlotte
Date Deposited: 18 Apr 2016 12:27
Last Modified: 08 Feb 2019 09:00

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